The stock of Upstream Bio Inc (NASDAQ: UPB) has decreased by -47.18% when compared to last closing price of $27.81.Despite this, the company has seen a loss of -50.00% in its stock price over the last five trading days. benzinga.com reported 2026-02-11 that The stock gave up its gains and is falling, probably on profit booking.
Is It Worth Investing in Upstream Bio Inc (NASDAQ: UPB) Right Now?
The 36-month beta value for UPB is at 2.04. Analysts have varying views on the stock, with 6 analysts rating it as a “buy”, 2 rating it as “overweight”, 0 as “hold”, and 0 as “sell”.
The public float for UPB is 25.46M, and currently, shorts hold a 12.51% of that float. The average trading volume for UPB on February 12, 2026 was 588.68K shares.
UPB’s Market Performance
UPB’s stock has seen a -50.00% decrease for the week, with a -53.60% drop in the past month and a -37.49% fall in the past quarter. The volatility ratio for the week is 19.54%, and the volatility levels for the past 30 days are at 9.48% for Upstream Bio Inc The simple moving average for the past 20 days is -49.75% for UPB’s stock, with a -23.42% simple moving average for the past 200 days.
Analysts’ Opinion of UPB
Many brokerage firms have already submitted their reports for UPB stocks, with Mizuho repeating the rating for UPB by listing it as a “Outperform”. The predicted price for UPB in the upcoming period, according to Mizuho is $51 based on the research report published on December 18, 2025 of the previous year 2025.
Evercore ISI, on the other hand, stated in their research note that they expect to see UPB reach a price target of $40. The rating they have provided for UPB stocks is “Outperform” according to the report published on November 18th, 2025.
UPB Trading at -48.89% from the 50-Day Moving Average
After a stumble in the market that brought UPB to its low price for the period of the last 52 weeks, the company was unable to rebound, for now settling with -56.38% of loss for the given period.
Volatility was left at 9.48%, however, over the last 30 days, the volatility rate increased by 19.54%.
Stock Fundamentals for UPB
Current profitability levels for the company are sitting at:
- -50.2% for the present operating margin
- 0.99% for the gross margin
The net margin for Upstream Bio Inc stands at -43.67%. The total capital return value is set at -0.37%. Equity return is now at value -40.80%, with -39.18% for asset returns.
Based on Upstream Bio Inc (UPB), the company’s capital structure generated 0.0 points at debt to capital in total, while cash flow to debt ratio is standing at -86.16.
Currently, EBITDA for the company is -$77.67 million with net debt to EBITDA at 0.52. When we switch over and look at the enterprise to sales, we see a ratio of 258.34. The receivables turnover for the company is 4.1for trailing twelve months and the total asset turnover is 0.01. The liquidity ratio also appears to be rather interesting for investors as it stands at 32.67.
Conclusion
In conclusion, Upstream Bio Inc (UPB) has had a bad performance lately. Opinion on the stock among analysts is bullish, with some giving it a “buy” rating and others a “hold”. It’s important to note that the stock is currently trading at a significant distance from its 50-day moving average and its 52-week high.